反应详情

3.00 g (12.1 mmol) 4-iodophenethylamine and 0.37 g (3.03 mmol) DMAP in 50 mL THF are cooled down to 0° C. 4.95 g (48.5 mmol) acetic anhydride are added and, after removing of the cooling bath, the reaction mixture is stirred for 5 h at r.t. The reaction mixture is quenched in ice cold water and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, DCM/MeOH 98.5/1.5).

1. customafter removing of the cooling bath
2. customThe reaction mixture is quenched in ice cold water
3. extractionextracted with EtOAc
4. dry with materialThe organic layer is dried with Na2SO4
5. customthe solvent is removed in vacuo
6. customThe crude product is purified by column chromatography (silica gel, DCM/MeOH 98.5/1.5)