反应详情

温度

0 °C

A mixture of 0.30 g (0.922 mmol) N-{1-methyl-2-[4-(2-methylsulfanyl-pyrimidin-4-ylethynyl)-phenyl]-ethyl}-acetamide (example 14.1) in 9 mL DCM is cooled down to 0° C. and charged with 0.27 g (1.10 mmol; 70% purity) 3-chloroperoxybenzoic acid. The mixture is stirred for 30 min at constant temperature. The mixture is poured onto sat. aq. NaHCO3 solution. The organic layer is separated, dried with Na2SO4 and filtered. The resulting mixture can be used directly used in the following reaction.

1. customThe organic layer is separated
2. dry with materialdried with Na2SO4
3. filtrationfiltered
4. customThe resulting mixture can be used directly used in the following reaction