反应详情

温度

60 °C

To 3.50 g (23.9 mmol) 4-ethynylphenyl benzoic acid in 20 mL THF are added 3.88 g (23.9 mmol) CDI. The mixture is stirred at 60° C. for 30 min and then charged with 2.11 mL (23.9 mmol) morpholine. The complete mixture is stirred under reflux for 5 h and at r.t. for 24 h. The solvent is removed in vacuo and the residue is purified by column chromatography (silica gel, EtOAc 100%).

1. stirringThe complete mixture is stirred
2. temperatureunder reflux for 5 h and at r.t. for 24 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by column chromatography (silica gel, EtOAc 100%)