反应详情

8.41 mg (0.10 mmol) butanoic acid are dissolved in 300 μL DMF together with 32.1 mg (0.10 mmol) TBTU and 50.0 μL (0.30 mmol) DIPEA and the mixture is stirred at r.t. for 5 min. 27.9 mg (0.10 mmol) 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-amine (I64) are added and the reaction mixture is stirred at 40° C. over night. The mixture is filtered through a plug of alox, eluted with DMF/MeOH (9/1) and the solvent is removed in vacuo. The residue is purified by HPLC.

1. stirringthe reaction mixture is stirred at 40° C. over night
2. filtrationThe mixture is filtered through a plug of alox
3. washeluted with DMF/MeOH (9/1)
4. customthe solvent is removed in vacuo
5. customThe residue is purified by HPLC