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HRID76190

反应详情

EQUATION

反应方程式

HRID 76190 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CNCCOC
HCID300977

N-(2-Methoxyethyl)methylamine

C4H11NO

结构：CC(=O)NC(C)Cc1ccc(C#Cc2ccnc(Cl)n2)cc1
HCID86669623

未命名化合物

PRODUCTS

生成物

1
结构：COCCN(C)c1nccc(C#Cc2ccc(CC(C)NC(C)=O)cc2)n1
HCID66614562

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

To 31.4 mg (0.10 mmol) N-(1-(4-((2-chloropyrimidin-4-yl)ethynyl)phenyl)propan-2-yl)-acetamide (170) and 25.8 μl (0.15 mmol) DIPEA in 1 mL NMP are added 26.7 mg (0.30 mmol) N-(2-methoxyethyl)methylamine. The reaction mixture is stirred in a sealed tube at 120° C. over night and purified by HPLC (MeOH/H2O/TFA).

WORKUP

后处理

  1. custompurified by HPLC (MeOH/H2O/TFA)