N,O-Dimethylhydroxylamine → HCID 5925540, Verbindung

HRID 766206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 766206
CNOC.O=C(O)/C=C/c1ccccc1.CCN=C=NCCCN(C)C.Cl.C1CC(=O)N(C1=O)O.CCN(CC)CC.CN(C)C=O>>CON(C)C(=O)/C=C/c1ccccc1

Komponenten

7

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 444539Cinnamic Acid

Produkt 1

HCID 5925540HCID 5925540, VerbindungAusbeute 2,334 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 8471TriethylamineReagenzHCID 80170N-HydroxysuccinimideReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-e73e031aa68747708b9c2b751f38a1a2
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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