Hydrochloric Acid → HCID 66886089, compound

HRID 76877Notes

Reaction equation

HRID 76877 reaction equation
C[O:2][C:3]([C:5]1([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([F:21])[CH:14]=2)[N:9]2[CH:10]=[N:11][CH:12]=[C:8]2[CH2:7][CH2:6]1)=[O:4].[Li+].[OH-].Cl>C1COCC1.O>[F:21][C:15]1[CH:14]=[C:13]([C:5]2([C:3]([OH:4])=[O:2])[N:9]3[CH:10]=[N:11][CH:12]=[C:8]3[CH2:7][CH2:6]2)[CH:18]=[CH:17][C:16]=1[O:19][CH3:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 588271365-(3-fluoro-4-methoxy-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-5-carboxylic acid methyl ester

Product 1

HCID 66886089HCID 66886089, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

5-(3-fluoro-4-methoxy-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-5-carboxylic acid methyl ester (0.530 g, 1.82 mmol) is dissolved in THF/water (20 mL) (3:2) and to the solution is added LiOH (0.230 g, 9.58 mmol). After 1 h, the solution is brought to pH 4-5 with 1 M HCl and then evaporated to dryness to give 5-(3-fluoro-4-methoxy-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-5-carboxylic acid that is used without further purification. MS (ESI) m/z 277.2 (M+H).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-694c17ff449441d98784de83a2c980ab
Source dataset
uspto-grants-2014_09
Patent number
US08835646B2

Reaction notes

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