反应详情

Method 2—Step b—Into a three necked round bottomed flask equipped with a magnetic stirrer, 2-(5-bromo-2-chlorophenyl)-1H-benzimidazole (30.7 g, 99.8 mmol) was suspended in THF(1 L). 50% NaOH (72.0 g, 598 mmol) was then added. The suspension was left at r.t. for 1 h under stirring. (BOC)2O (37.0 g, 169.7 mmol) was dissolved in THF (200 mL) and added to the reaction mixture. The reaction was left under stirring overnight. The solvent was evaporated under reduced pressure. The obtained residue was diluted with water (500 mL) filtered and dried under vacuum (60° C.), to give 39.8 g of a brown solid. (98%).

1. customMethod 2—Step b—Into a three necked round bottomed flask equipped with a magnetic stirrer
2. additionadded to the reaction mixture
3. waitThe reaction was left
4. stirringunder stirring overnight
5. customThe solvent was evaporated under reduced pressure
6. additionThe obtained residue was diluted with water (500 mL)
7. filtrationfiltered
8. customdried under vacuum (60° C.)