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HRID77252

反应详情

EQUATION

反应方程式

HRID 77252 的结构方程式

REACTANTS

反应物

2
结构：CCCCCCCCCC=O
HCID8175

Decanal

C10H20O

结构：C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O
HCID448601

Octreotide

C49H66N10O10S2

PRODUCTS

生成物

1
结构：CCCCCCCCCC=O.C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O
HCID86614453

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)[O-]
溶剂HCID175

Acetate

C2H3O2-

结构：[BH3-]C#N.[Na+]
溶剂HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

PROCEDURE

实验过程

50 mg of octreotide was dissolved in 2 mL of 20 mM sodium cyanoborohydride (Mw 62.84, NaCNBH3) (2.51 mg) solution in 0.1 M acetate buffer at pH 5. 13.7 mg of Decanal (Mw 156.27) (OCT:DCL=1:2) was added by direct injection to the peptide solution. The reaction was allowed to proceed overnight at 4° C. The mixture was separated by centrifugation. The precipitated PAL-OCT was freeze-dried.

WORKUP

后处理

  1. customThe mixture was separated by centrifugation
  2. customThe precipitated PAL-OCT was freeze-dried