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HRID77319

反应详情

EQUATION

反应方程式

HRID 77319 的结构方程式

REACTANTS

反应物

1
结构：CC(C)CCN([C@@H](C(=O)OC(C)(C)C)C(C)C)S(=O)(=O)c1ccc2cc(O)ccc2c1
HCID67155390

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CCN([C@@H](C(=O)O)C(C)C)S(=O)(=O)c1ccc2cc(O)ccc2c1
HCID67155085

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine tert-butyl ester (0.33 g, 0.74 mmol) is dissolved in 4 N hydrochloric acid in ethyl acetate (50 mL), and the reaction is allowed to stir at ambient temperature for 16 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (15% hexanes-ethyl acetate) to afford the title compound as a colorless oil (0.26 g, 90% yield). LCMS (m/z): (394.24, M+1; 392.27, M−1).

WORKUP

后处理

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by column chromatography (15% hexanes-ethyl acetate)