反应详情

温度

120 °C

To 37.63 gm (0.3163 mole) of benzotriazole and 35 gm of potassium carbonate in Dimethylformamide (DMF) (350 ml) was added slowly under stirring 82 gm of 2-chloromethyl-8-(4,6-dimethoxy-pyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4,5]decane (intermediate for compound 7) in DMF (300 ml). After the addition, reaction mixture was heated to 120° C. and maintained for 30 hrs. The reaction mixture was cooled to room temperature 28° C. and filtered. The solvent was distilled off to get the product. It was a thick dark brown liquid. Yield of product was 90%

1. additionAfter the addition, reaction mixture
2. temperaturemaintained for 30 hrs
3. temperatureThe reaction mixture was cooled to room temperature 28° C.
4. filtrationfiltered
5. distillationThe solvent was distilled off
6. customto get the product