Tetrahydrofuran → 4-Cyclopropylmethoxy-N-methyl-N-((S)-6-{[(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide

HRID 77411Notes

Reaction equation

HRID 77411 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:27]=[CH:26][C:9]([C:10]([N:12]([C@H:14]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([CH:24]=O)[CH:20]=4)[CH2:15]3)[CH3:13])=[O:11])=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.C1COCC1.[O:33]1[CH2:38][CH2:37][CH:36]([CH2:39][NH2:40])[CH2:35][CH2:34]1.C([BH3-])#N.[Na+]>C(O)(=O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:27]=[CH:26][C:9]([C:10]([N:12]([CH3:13])[C@H:14]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][CH:18]=[C:19]([CH2:24][NH:40][CH2:39][CH:36]5[CH2:37][CH2:38][O:33][CH2:34][CH2:35]5)[CH:20]=4)[CH2:15]3)=[O:11])=[CH:8][CH:7]=2)[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 27732104-AminomethyltetrahydropyranHCID 5003444Sodium cyanoborohydrideHCID 867627474-cyclopropylmethoxy-N-((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

Product 1

HCID 468691334-Cyclopropylmethoxy-N-methyl-N-((S)-6-{[(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide (0.20 g), THF (5 ml), C-(tetrahydropyran-4-yl)methylamine (63 mg) and acetic acid (33 mg) was added polymer-bound sodium cyanoborohydride (0.55 mmol), and the suspension was shaken at room temperature for 12 hours. The polymer was filtered off with suction and the filtrate was concentrated. The residue was purified by preparative HPLC. The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3); MS (ESI): 463.3 (M+H+).

Workup

  1. filtrationThe polymer was filtered off with suction
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by preparative HPLC
  4. customThe product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3)

Sources & evidence

ORD record
ord-1fbbb48526a94d23a85b6de44a3fc1dc
Source dataset
uspto-grants-2014_09
Patent number
US08841290B2

Reaction notes

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