Pyrrolidine → [(S)-6-(pyrrolidine-1-carbonyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamic acid tert-butyl ester

HRID 77424Notes

Reaction equation

HRID 77424 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:18][CH2:17][C:16]2[CH:15]=[C:14]([C:19](O)=[O:20])[CH:13]=[CH:12][C:11]=2[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:20])[CH:15]=2)[CH2:10]1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 66663497(S)-6-tert-butoxycarbonylamino-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

Product 1

HCID 66663930[(S)-6-(pyrrolidine-1-carbonyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamic acid tert-butyl ester

Procedure

According to method G, (S)-6-tert-butoxycarbonylamino-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid was reacted with pyrrolidine. The product was thus obtained with the molecular weight of 344.46 (C20H28N2O3); MS (ESI): 345 (M+H+).

Workup

  1. customThe product was thus obtained with the molecular weight of 344.46 (C20H28N2O3)

Sources & evidence

ORD record
ord-20508aeff6de43bba9250bbf1c139661
Source dataset
uspto-grants-2014_09
Patent number
US08841290B2

Reaction notes

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