反应详情

To a solution of CDI (2 g, 12.33 mmol), in DCM (25 mL) was added isopropyl alcohol (0.95 mL, 12.33 mmol) at 0° C. The reaction mixture was stirred at r.t. and progress of the reaction was monitored by TLC. On completion, the reaction mixture was diluted with DCM (100 mL). The organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, 1:10 ethyl acetate:Pet. ether) to provide title compound (330 mg, 77%) as colourless viscous oil.

1. washThe organic layer was washed with water (25 mL), brine (25 mL)
2. dry with materialdried over anhydrous sodium sulphate
3. concentrationconcentrated in vacuo
4. customThe residue was purified by column chromatography (silica gel, 1:10 ethyl acetate:Pet. ether)