反应详情

温度

70 °C

To a solution of 2-nitro-5-trimethylsilanylethynyl-pyridine (405 mg, 1.84 mmol) described in Manufacturing Example 28-1-1 in tetrahydrofuran (10 mL) and water (5 mL) were added iron powder (514 mg, 9.21 mmol) and ammonium chloride (197 mg, 3.69 mmol) at room temperature, which was stirred for 75 minutes at 70° C. The reaction solution was cooled to room temperature and filtered through a Celite pad, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1) to obtain the title compound (319 mg, 91%).

1. temperatureThe reaction solution was cooled to room temperature
2. filtrationfiltered through a Celite pad
3. concentrationthe filtrate was concentrated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1)