反应详情

温度

100 °C

To a mixture of 4-(5-chloro-furan-2-ylmethyl)-benzaldehyde (270 mg, 1.2 mmol) described in Manufacturing Example 62-1-4 and acetic acid (3 mL) were added nitromethane (500 μL, 9.3 mmol) and ammonium acetate (290 mg, 3.7 mmol) at room temperature, which was stirred for 3 hours at 100° C. The reaction mixture was cooled to room temperature, and extracted by addition of water and ethyl acetate. This organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, and was concentrated under a reduced pressure. To a mixture of acetic acid (0.6 mL) and dimethyl sulfoxide (10 mL) was added sodium borohydride (76 mg, 2.0 mmol) at room temperature while cooling appropriately, which was stirred for 10 minutes at room temperature. Water was added to the reaction solution at room temperature, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride. The organic layer was concentrated under a reduced pressure, and the residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:5) to obtain the title compound (210 mg, 62%).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted by addition of water and ethyl acetate
3. washThis organic layer was washed with saturated aqueous sodium chloride
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationwas concentrated under a reduced pressure
6. additionTo a mixture of acetic acid (0.6 mL) and dimethyl sulfoxide (10 mL)
7. temperaturewhile cooling appropriately
8. stirringwhich was stirred for 10 minutes at room temperature
9. extractionwhich was then extracted with ethyl acetate
10. washThe organic layer was washed with saturated aqueous sodium chloride
11. concentrationThe organic layer was concentrated under a reduced pressure
12. customthe residue was purified by neutral silica gel column chromatography (ethyl acetate:heptane=1:5)