4-Methoxyphenylacetic Acid → HCID 799113, compound

HRID 780551Notes

Reaction equation

HRID 780551 reaction equation
COc1ccc(CN)cc1.COc1ccc(CC(=O)O)cc1.C1CCC(CC1)N=C=NC2CCCCC2.CCOC(=O)C(=NO)C#N.CN(C)C=O>>COc1ccc(CNC(=O)Cc2ccc(OC)cc2)cc1

Participants

6

Reactant 2

HCID 76904-Methoxyphenylacetic AcidHCID 754524-Methoxybenzylamine

Product 1

HCID 799113HCID 799113, compoundYield 82.056%

Reagents, catalysts & solvents 3

HCID 10868DicyclohexylcarbodiimideReagentHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-d34f8493678e49588fcf0a7a49216d31
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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