反应详情

温度

100 °C

To a mixture of 3-(1-(4-bromo-benzyl)-1H-pyrazol-4-yl)-pyridin-2-ylamine (24 mg, 0.073 mmol) described in Manufacturing Example 195-1-1 and 1,4-dioxane (1.5 mL) were added water (150 μL), cesium carbonate (95 mg, 0.29 mmol), sodium cyclopropylmethoxymethyl trifluoroborate (19 mg, 0.11 mmol) described in Manufacturing Example 195-2-2, palladium (II) acetate (1.6 mg, 0.0073 mmol), and (±)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (4.5 mg, 0.0073 mmol) at room temperature, which was stirred for 6 hours at 100° C. under nitrogen atmosphere. The reaction mixture was cooled to room temperature, after which water and ethyl acetate were added and the mixture was filtered through a Celite pad. The organic layer of the filtrate was washed with saturated aqueous sodium chloride, and was concentrated under a reduced pressure. The residue thus obtained was purified by reverse-phase high performance liquid chromatography (using an acetonitrile-water mobile phase containing 0.1% trifluoroacetic acid), after which triethylamine was added to a mixture of the resulting target product and the mobile phase, thereby rendering the mobile phase basic, and the solvent was evaporated under a reduced pressure. The residue thus obtained was filtered through NH silica gel (ethyl acetate) to obtain the title compound (1.6 mg, 6.6%).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationthe mixture was filtered through a Celite pad
3. washThe organic layer of the filtrate was washed with saturated aqueous sodium chloride
4. concentrationwas concentrated under a reduced pressure
5. customThe residue thus obtained
6. customwas purified by reverse-phase high performance liquid chromatography (
7. additioncontaining 0.1% trifluoroacetic acid), after which triethylamine
8. additionwas added to a mixture of the resulting target product
9. customthe solvent was evaporated under a reduced pressure
10. customThe residue thus obtained
11. filtrationwas filtered through NH silica gel (ethyl acetate)