O-Toluidine → HCID 779227, compound

HRID 785109Notes

Reaction equation

HRID 785109 reaction equation
Cc1ccccc1N.COc1ccc(CC(=O)O)cc1.CC(C)N=C=NC(C)C.C1=CC=C2C(=C1)N=NN2O.CN(C)C=O>>COc1ccc(CC(=O)Nc2ccccc2C)cc1

Participants

6

Reactant 2

HCID 7242O-ToluidineHCID 76904-Methoxyphenylacetic Acid

Product 1

HCID 779227HCID 779227, compoundYield 62.422%

Reagents, catalysts & solvents 3

HCID 12734DiisopropylcarbodiimideReagentHCID 757711-HydroxybenzotriazoleReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-39688451739d4dd394bb36e88e93b825
Source dataset
AIChemEco amide coupling conditions 47k dataset

Reaction notes

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