Triethylamine → CID 136510283

HRID 78568Notes

Reaction equation

HRID 78568 reaction equation
[NH2:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.Cl.[NH2:12][OH:13].C(N(CC)CC)C>CO>[NH2:1][C:2]1[C:3]([C:9](=[N:12][OH:13])[NH2:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 110526113-Amino-6-bromopyrazine-2-carbonitrile

Product 1

HCID 136510283CID 136510283Yield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-amino-6-bromo-pyrazine-2-carbonitrile (1 g, 5.025 mmol) in MeOH (20 mL) was cooled to 0° C. and treated with hydroxylamine hydrochloride (349.2 mg, 5.025 mmol) and triethylamine (508.5 mg, 700.4 μL, 5.025 mmol) and the reaction allowed to warm to ambient temperature. After a period of 2 hours a precipitate was observed which was filtered off. The resultant filtrate was evaporated to dryness and triturated with MeOH to furnish further product as a beige solid (771 mg, 78% Yield).

Workup

  1. filtrationwhich was filtered off
  2. customThe resultant filtrate was evaporated to dryness
  3. customtriturated with MeOH

Sources & evidence

ORD record
ord-53329b6eb39a498fb6cb28cd5456c9c3
Source dataset
uspto-grants-2014_09
Patent number
US08841308B2

Reaction notes

Loading…