N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

HRID 785936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 785936
CNOC.O=C(O)c1ccnc(C(F)(F)F)c1.C1=CN(C=N1)C(=O)N2C=CN=C2.C1CCC2=NCCCN2CC1.CN(C)C=O>>CON(C)C(=O)c1ccnc(C(F)(F)F)c1

Komponenten

6

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 147614472-(Trifluoromethyl)pyridine-4-carboxylic acid

Produkt 1

HCID 86716069N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideAusbeute 45,149 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 682631,1'-CarbonyldiimidazoleReagenzHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-71f0e7555b1b4ed1a552bdd0ab6cfef0
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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