反应详情

温度

50 °C

A mixture of (2-bromophenyl)boronic acid (100 mg, 0.4979 mmol), tert-butyl N-[5-bromo-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-N-tert-butoxycarbonyl-carbamate (258.1 mg, 0.4979 mmol), potassium carbonate (206.5 mg, 1.494 mmol) and triphenylphosphane palladium (13.06 mg, 11.54 μL, 0.04979 mmol) in DMF (3 mL) was heated at 50° C. for 1 h. The reaction mixture was cooled to room temperature and filtered through a Celite,™ pad. The pad was washed with ethyl acetate (1×10 mL) and the combined filtrates were washed with water (2×10 mL) and brine (1×10 mL), dried over MgSO4 and concentrated to leave the product as a solid which was used directly in the next step without further purification.

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationfiltered through a Celite,™ pad
3. washThe pad was washed with ethyl acetate (1×10 mL)
4. washthe combined filtrates were washed with water (2×10 mL) and brine (1×10 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated