反应详情

To a solution of 4-tert-butyl-2-(phenylthio)-N-(3-sulfamoylphenyl)benzamide (15.4 mg, 0.035 mmol) in 1,1,1,3,3,3-hexafluoropropan-2-ol (0.3 mL) was added H2O2 (30% wt in water, 0.01 mL, 0.07 mmol). The reaction was stirred at room temperature for 40 min, and saturated NaHCO3(aq) and CH2Cl2 (1 mL each) were added. The organic layer was filtered through a pad of Na2SO4 and concentrated. The product was purified by reverse phase HPLC (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)) to give 4-tert-butyl-2-(phenylsulfinyl)-N-(3-sulfamoylphenyl)benzamide. LC/MS: m/z 457.4 (M+H)+ at 1.54 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

1. filtrationThe organic layer was filtered through a pad of Na2SO4
2. concentrationconcentrated
3. customThe product was purified by reverse phase HPLC (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA))