Hydrochloric Acid → HCID 21991412, compound

HRID 7916Notes

Reaction equation

HRID 7916 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[C:16](=[O:33])[N:17]([CH2:29][CH:30]([CH3:32])[CH3:31])[N:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[C:23]([F:28])[CH:22]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:34].C(OCC)C>C(OCC)(=O)C>[ClH:34].[ClH:34].[F:28][C:23]1[CH:22]=[C:21]([C:19]2[CH:20]=[C:15]([CH2:14][N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:16](=[O:33])[N:17]([CH2:29][CH:30]([CH3:31])[CH3:32])[N:18]=2)[CH:26]=[CH:25][C:24]=1[CH3:27]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 21991456HCID 21991456, compound

Product 1

HCID 21991412HCID 21991412, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 4-(4-tert-butoxycarbonyl-1-piperazinyl)methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one (115 mg, 0.25 mmol) in ethyl acetate (2 mL) was added a 4 mol/L solution (2 mL) of hydrochloric acid in ethyl acetate, and the mixture was stirred at 50 for 1 hour. The temperature of the reaction mixture was allowed to drop back to room temperature, and then, diethyl ether was added. The precipitate was collected to yield the title compound as a colorless crystalline powder (81.1 mg, 75.0%).

Workup

  1. customto drop back to room temperature
  2. customThe precipitate was collected

Sources & evidence

ORD record
ord-255e4d7378f140328c7e6ec5faa61ba2
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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