反应详情

温度

70 °C

To ethyl 3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridine-7-carboxylate (430 mg, 0.891 mmol; prepared as in Example 23) in THF/H2O (6 mL/1 mL) was added lithium hydroxide (21.3 mg, 0.891 mmol). The reaction mixture was sealed and heated to 70° C. for 2 hours. The mixture was cooled to ambient temperature and HCl (0.45 mL, 4M in dioxane) was added. The mixture was concentrated under reduced pressure to give crude product (410 mg, mixed with LiCl).

1. customThe reaction mixture was sealed
2. temperatureThe mixture was cooled to ambient temperature
3. concentrationThe mixture was concentrated under reduced pressure