反应详情

A solution of 7-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (77 mg, 0.142 mmol) in water (4 mL), trifluoroacetic acid (4 mL) and 1,4-dioxane (1 mL) was stirred for 1 hour at ambient temperature. The mixture was concentrated under reduced pressure to give a residual oil. The oil was dissolved in a mixture of diethyl ether, dichloromethane and methanol. A solution of hydrogen chloride (0.5 mL; 4M in 1,4-dioxane) was added. The mixture was concentrated under reduced pressure and placed under high vacuum for 16 hours to provide 7-(2,3-dihydroxypropoxy)-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide dihydrochloride (74 mg) as a beige solid. MS (APCI), positive scan, m/z=501.2 (M+H).

1. concentrationThe mixture was concentrated under reduced pressure
2. customto give a residual oil
3. concentrationThe mixture was concentrated under reduced pressure