反应详情

LiOH—H2O (0.09 g, 2.1 mmol) was added to a solution of methyl 3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoate (0.64 g, 1.9 mmol) in 2:1 THF:H2O (20 mL). The reaction was then stirred for 3 hours at room temperature and then diluted with H2O (50 mL) and washed with ether (50 mL). The aqueous layer was next acidified with solid KHSO4, saturated with solid NaCl, and extracted with DCM. The combined organic extracts were dried (Na2SO4), filtered, concentrated, and dried in vacuo to give 3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoic acid (0.523 g, 85%) as a solid. MS ESI (−) m/z 312 detected.

1. washwashed with ether (50 mL)
2. extractionextracted with DCM
3. dry with materialThe combined organic extracts were dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated
6. customdried in vacuo