Tetrahydrofuran → 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-5-nitrobenzoic acid

HRID 799411Notes

Reaction equation

HRID 799411 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([I:9])[cH:8]1.[F:20][c:21]1[c:22]([C:23](=[O:24])[OH:25])[cH:26][c:27]([N+:32](=[O:33])[O-:34])[c:28]([F:31])[c:29]1[F:30].[Li+:10]>>[F:1][c:2]1[c:3]([NH:4][c:21]2[c:22]([C:23](=[O:24])[OH:25])[cH:26][c:27]([N+:32](=[O:33])[O-:34])[c:28]([F:31])[c:29]2[F:30])[cH:5][cH:6][c:7]([I:9])[cH:8]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 1856942-Fluoro-4-iodoanilineHCID 3280088Npc316347HCID 158712412,3,4-Trifluoro-5-nitrobenzoic acid

Product 1

HCID 210742923,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-5-nitrobenzoic acid

Sources & evidence

ORD record
ord-18d8924f4b0342c3838149a270c7fa3b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…