Tetrahydrofuran → 1-[4-(4-Chlorophenoxy)phenyl]-2-[3-(trifluoromethyl)phenyl]pyrrolidine

HRID 799446Notes

Reaction equation

HRID 799446 reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH:31]12[CH2:32][CH2:33][CH2:34][CH:35]([BH:36]1)[CH2:37][CH2:38][CH2:39]2.[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][c:10]([N:13]3[C:14](=[O:28])[CH2:15][CH2:16][CH:17]3[c:18]3[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][cH:23]3)[cH:11][cH:12]2)[cH:29][cH:30]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][c:10]([N:13]3[CH2:14][CH2:15][CH2:16][CH:17]3[c:18]3[cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[cH:21][cH:22][cH:23]3)[cH:11][cH:12]2)[cH:29][cH:30]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 789669-Borabicyclo(3.3.1)nonaneHCID 594860141-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one

Product 1

HCID 687035661-[4-(4-Chlorophenoxy)phenyl]-2-[3-(trifluoromethyl)phenyl]pyrrolidine

Sources & evidence

ORD record
ord-a45abe09bea94824b07c3fc2aee2be65
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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