Tetrahydrofuran → 1-(6-Methyl-pyrid-3-yl)-3,4-dihydro-4,4-dimethyl-7-bromo-naphthalene

HRID 799865Notes

Reaction equation

HRID 799865 reaction equation
[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[CH3:1][c:2]1[cH:3][cH:4][c:5]([Br:8])[cH:6][n:7]1.[CH3:20][C:21]1([CH3:33])[CH2:22][CH2:23][C:24](=[O:32])[c:25]2[cH:26][c:27]([Br:31])[cH:28][cH:29][c:30]21.[CH3:39][CH2:40][O:41][C:42](=[O:43])[CH3:44].[CH3:9][CH2:10][CH2:11][CH2:12][Li:13]>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([C:24]2=[CH:23][CH2:22][C:21]([CH3:20])([CH3:33])[c:30]3[c:25]2[cH:26][c:27]([Br:31])[cH:28][cH:29]3)[cH:6][n:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 12010205-Bromo-2-methylpyridineHCID 107533577-Bromo-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-oneHCID 178418339Butyllithium

Product 1

HCID 186200651-(6-Methyl-pyrid-3-yl)-3,4-dihydro-4,4-dimethyl-7-bromo-naphthalene

Sources & evidence

ORD record
ord-4ff0cb2a538f47ef87c5b74eb40fcb7f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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