Imidazole → Clioquinol, o-(tert-butyldimethylsilyl)-

HRID 800732Notes

Reaction equation

HRID 800732 reaction equation
[C:14]([CH3:15])([CH3:16])([CH3:17])[Si:18]([Cl:19])([CH3:20])[CH3:21].[Cl:1][c:2]1[c:3]2[cH:4][cH:5][cH:6][n:7][c:8]2[c:9]([OH:13])[c:10]([I:12])[cH:11]1.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31].[nH:22]1[cH:23][cH:24][n:25][cH:26]1>>[Cl:1][c:2]1[c:3]2[cH:4][cH:5][cH:6][n:7][c:8]2[c:9]([O:13][Si:18]([C:14]([CH3:15])([CH3:16])[CH3:17])([CH3:20])[CH3:21])[c:10]([I:12])[cH:11]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 2788ClioquinolHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chloride

Product 1

HCID 632411Clioquinol, o-(tert-butyldimethylsilyl)-

Sources & evidence

ORD record
ord-39eb987d37b5455d9593bc61a4ffb522
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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