Water → N-[5-[methyl(propan-2-yl)amino]-2-[2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide

HRID 800797Notes

Reaction equation

HRID 800797 reaction equation
[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[CH:46]([OH:47])([CH3:48])[CH3:49].[Cl:23][c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12.[Cl:50][CH2:51][Cl:52].[NH2:1][CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([NH:18][C:19]([CH3:20])=[O:21])[CH2:9][CH:10]([N:13]([CH3:14])[CH:15]([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1.[OH2:45]>>[NH:1]([CH:2]1[C:3](=[O:22])[N:4]([CH:7]2[CH:8]([NH:18][C:19]([CH3:20])=[O:21])[CH2:9][CH:10]([N:13]([CH3:14])[CH:15]([CH3:16])[CH3:17])[CH2:11][CH2:12]2)[CH2:5][CH2:6]1)[c:24]1[n:25][cH:26][n:27][c:28]2[cH:29][cH:30][c:31]([C:34]([F:35])([F:36])[F:37])[cH:32][c:33]12

Participants

7

Reactant 6

HCID 962WaterHCID 3776IsopropanolHCID 6344DichloromethaneHCID 8471TriethylamineHCID 210750954-Chloro-6-(trifluoromethyl)quinazolineHCID 74943966N-[2-(3-amino-2-oxopyrrolidin-1-yl)-5-[methyl(propan-2-yl)amino]cyclohexyl]acetamide

Product 1

HCID 74109147N-[5-[methyl(propan-2-yl)amino]-2-[2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide

Sources & evidence

ORD record
ord-30b0725a7b1f429f99439caf2508bac9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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