Tetrahydrofuran → tert-Butyl 4-(2-methoxy-2-oxo-1-phenylethyl)piperazine-1-carboxylate

HRID 801093Notes

Reaction equation

HRID 801093 reaction equation
[C:20](=[O:21])([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[N:27]1[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1.[CH3:13][CH2:14][N:15]([CH2:16][CH3:17])[CH2:18][CH3:19].[CH3:1][O:2][C:3]([CH:4]([Br:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)=[O:12].[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1>>[CH3:1][O:2][C:3]([CH:4]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[N:30]1[CH2:29][CH2:28][N:27]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:32][CH2:31]1)=[O:12]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 137806Benzeneacetic acid, alpha-bromo-, methyl esterHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 23386132tert-Butyl 4-(2-methoxy-2-oxo-1-phenylethyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-8e5ee5a72fc24abda5796ab7a2ccc700
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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