Tetrahydrofuran → Tert-butyl 4-[2-fluoro-4-[5-(1,2-oxazol-3-yloxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate

HRID 801125Notes

Reaction equation

HRID 801125 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([F:28])[cH:16][c:17]([N:20]3[C:21](=[O:27])[O:22][CH:23]([CH2:25][OH:26])[CH2:24]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1.[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1.[OH:29][c:30]1[n:31][o:32][cH:33][cH:34]1.[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([F:28])[cH:16][c:17]([N:20]3[C:21](=[O:27])[O:22][CH:23]([CH2:25][O:26][c:30]4[n:31][o:32][cH:33][cH:34]4)[CH2:24]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 229959393-[3-Fluoro-4-(4-tert-butoxycarbonylpiperazin-1-yl)phenyl]-5-hydroxymethyl-2-oxazolidinoneHCID 178516613HCID 178516613, compound

Product 1

HCID 57323192Tert-butyl 4-[2-fluoro-4-[5-(1,2-oxazol-3-yloxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-deeb7e2fd8d947f2961150317834491c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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