Tetrahydrofuran → Tert-butyl 3-amino-1-(4-chlorophenyl)propylcarbamate

HRID 801146Notes

Reaction equation

HRID 801146 reaction equation
[Al+3:2].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[Cl:7][c:8]1[cH:9][cH:10][c:11]([CH:14]([CH2:15][C:16]#[N:17])[NH:18][C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[cH:12][cH:13]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[Cl:7][c:8]1[cH:9][cH:10][c:11]([CH:14]([CH2:15][CH2:16][NH2:17])[NH:18][C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 57750327Tert-butyl 1-(4-chlorophenyl)-2-cyanoethylcarbamate

Product 1

HCID 24729697Tert-butyl 3-amino-1-(4-chlorophenyl)propylcarbamate

Sources & evidence

ORD record
ord-74e0ae559690467d8d2dbd71854026d9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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