Trifluoroacetic acid → N-(2-chloro-4-(6-cyano-7-hydroxyquinolin-4-yloxy)phenyl)-N'-methylurea

HRID 801600Notes

Reaction equation

HRID 801600 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([C:32]#[N:33])[cH:11][c:12]2[c:13]([O:19][c:20]3[cH:21][c:22]([Cl:31])[c:23]([NH:26][C:27](=[O:28])[NH:29][CH3:30])[cH:24][cH:25]3)[cH:14][cH:15][n:16][c:17]2[cH:18]1.[OH:42][C:43]([C:44]([F:45])([F:46])[F:47])=[O:48].[c:34]1([S:35][CH3:36])[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[OH:8][c:9]1[c:10]([C:32]#[N:33])[cH:11][c:12]2[c:13]([O:19][c:20]3[cH:21][c:22]([Cl:31])[c:23]([NH:26][C:27](=[O:28])[NH:29][CH3:30])[cH:24][cH:25]3)[cH:14][cH:15][n:16][c:17]2[cH:18]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 22936876HCID 22936876, compound

Product 1

HCID 135829408N-(2-chloro-4-(6-cyano-7-hydroxyquinolin-4-yloxy)phenyl)-N'-methylurea

Sources & evidence

ORD record
ord-76c9174f7fd748bb858abac4f9ac4b15
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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