Ammonium → tert-Butyl 4-azido-3-hydroxypiperidine-1-carboxylate

HRID 801959Notes

Reaction equation

HRID 801959 reaction equation
[CH3:21][CH2:22][OH:23].[CH:7]12[CH2:8][N:9]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:10][CH2:11][CH:12]1[O:13]2.[Cl-:5].[N-:2]=[N+:3]=[N-:4].[NH4+:6].[Na+:1].[OH2:24]>>[N:2](=[N+:3]=[N-:4])[CH:12]1[CH:7]([OH:13])[CH2:8][N:9]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:10][CH2:11]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 702EthanolHCID 923Sodium ionHCID 962WaterHCID 33558AzideHCID 21991116tert-Butyl 7-Oxa-3-azabicyclo(4.1.0)heptane-3-carboxylate

Product 1

HCID 21874176tert-Butyl 4-azido-3-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-2b483246727048aba95d3fcedbd7a318
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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