Hydrochloric Acid → 2-Cyclohexyl-N-(2,6-dichloro-4-methoxy-benzyl)-4-hydroxy-butyramide

HRID 802333Notes

Reaction equation

HRID 802333 reaction equation
[CH3:14][Al:15]([CH3:16])[CH3:17].[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[CH:18]1([CH:24]2[C:25](=[O:29])[O:26][CH2:27][CH2:28]2)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1.[Cl:2][c:3]1[c:4]([CH2:5][NH2:6])[c:7]([Cl:13])[cH:8][c:9]([O:11][CH3:12])[cH:10]1.[ClH:1]>>[Cl:2][c:3]1[c:4]([CH2:5][NH:6][C:25]([CH:24]([CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:28][CH2:27][OH:26])=[O:29])[c:7]([Cl:13])[cH:8][c:9]([O:11][CH3:12])[cH:10]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 157703822,6-Dichloro-4-methoxybenzenemethanamineHCID 16682925TrimethylaluminumHCID 220132343-Cyclohexyl-dihydro-furan-2-one

Product 1

HCID 673553892-Cyclohexyl-N-(2,6-dichloro-4-methoxy-benzyl)-4-hydroxy-butyramide

Sources & evidence

ORD record
ord-05b60d3b0f23401fb34862cd165ed8a1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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