Dimethylformamide → tert-Butyl 4-chloro-3-formylpyridin-2-ylcarbamate

HRID 802516Notes

Reaction equation

HRID 802516 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:16][CH2:17][CH2:18][CH2:19][Li:20].[CH3:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[Cl:1][c:2]1[cH:3][c:4]([NH:8][C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[n:5][cH:6][cH:7]1.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31]>>[Cl:1][c:2]1[c:3]([CH:28]=[O:27])[c:4]([NH:8][C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[n:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 1516418tert-butyl N-(4-chloropyridin-2-yl)carbamateHCID 178418339Butyllithium

Product 1

HCID 46204204tert-Butyl 4-chloro-3-formylpyridin-2-ylcarbamate

Sources & evidence

ORD record
ord-e521f5a78f09475f96e38f927db6a197
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…