Hydrochloric Acid → 5-(6-(5,6-difluoroindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 802592Notes

Reaction equation

HRID 802592 reaction equation
[B-:41]([F:42])([F:43])([F:44])[F:45].[ClH:1].[F:30][c:31]1[cH:32][c:33]2[c:37]([cH:38][c:39]1[F:40])[NH:36][CH2:35][CH2:34]2.[O:2]=[C:3]1[NH:4][c:5]2[n:6][cH:7][cH:8][cH:9][c:10]2[C:11]12[CH2:12][c:13]1[cH:14][cH:15][c:16]([NH:20][c:21]3[cH:22][c:23]([C:27](=[O:28])[OH:29])[n:24][cH:25][n:26]3)[cH:17][c:18]1[CH2:19]2.[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[cH:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[O:2]=[C:3]1[NH:4][c:5]2[n:6][cH:7][cH:8][cH:9][c:10]2[C:11]12[CH2:12][c:13]1[cH:14][cH:15][c:16]([NH:20][c:21]3[cH:22][c:23]([C:27](=[O:28])[N:36]4[CH2:35][CH2:34][c:33]5[cH:32][c:31]([F:30])[c:39]([F:40])[cH:38][c:37]54)[n:24][cH:25][n:26]3)[cH:17][c:18]1[CH2:19]2

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 167925945,6-DifluoroindolineHCID 581174936-[(2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl)amino]pyrimidine-4-carboxylic acid

Product 1

HCID 498010885-(6-(5,6-difluoroindoline-1-carbonyl)pyrimidin-4-ylamino)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Sources & evidence

ORD record
ord-1526c21161c540ec9d8aa35682136606
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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