Dimethylformamide → Tert-butyl 2,2-difluoro-4-(5-methylthiophene-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

HRID 802700Notes

Reaction equation

[CH3:45][c:46]1[cH:47][cH:48][c:49]([C:51](=[O:52])[OH:53])[s:50]1.[CH3:54][CH2:55][N:56]([CH2:57][CH3:58])[CH2:59][CH3:60].[F:25][C:26]1([F:44])[O:27][C:28]2([CH2:29][NH:30][CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2.[O:61]=[CH:62][N:63]([CH3:64])[CH3:65].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[F:25][C:26]1([F:44])[O:27][C:28]2([CH2:29][N:30]([C:51]([c:49]3[cH:48][cH:47][c:46]([CH3:45])[s:50]3)=[O:52])[CH2:31]1)[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]2