Tetrahydrofuran → 5-Bromo-2-chloropyridine-3-carbaldehyde

HRID 802978Notes

Reaction equation

HRID 802978 reaction equation
[Al+3:16].[Br:1][c:2]1[cH:3][n:4][c:5]([Cl:14])[c:6]([C:7](=[O:8])[N:9]([O:10][CH3:11])[CH3:12])[cH:13]1.[CH2:21]1[O:22][CH2:23][CH2:24][CH2:25]1.[H-:15].[H-:18].[H-:19].[H-:20].[Li+:17]>>[Br:1][c:2]1[cH:3][n:4][c:5]([Cl:14])[c:6]([CH:7]=[O:8])[cH:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 568289985-Bromo-2-chloro-N-methoxy-N-methylnicotinamide

Product 1

HCID 230909885-Bromo-2-chloropyridine-3-carbaldehyde

Sources & evidence

ORD record
ord-1d132dde354140cda2dc57a47558f9fb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…