Phenethylamine → 3-(2-Phenylethylamino)methylenedihydrofuran-2-one

HRID 80332Notes

Reaction equation

[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[C:10]1([CH2:16][CH2:17][NH2:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([CH2:16][CH2:17][NH:18][CH:3]=[C:4]2[CH2:8][CH2:7][O:6][C:5]2=[O:9])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 1001Phenethylamine

HCID 66988753HCID 66988753, compound

Product 1

HCID 669886533-(2-Phenylethylamino)methylenedihydrofuran-2-oneYield 75%

Procedure

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (50 mmol) and 2-phenylethylamine (55 mmol) and proceeding according to the abovementioned method A1, 3-(2-phenylethylamino)methylenedihydrofuran-2-one (8.14 g, efficiency: 75%) is produced in the form of a white powder.

Sources & evidence

ORD record: ord-df8ce6a561ad4516a4a1bb34bb961ffd
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846125B2

Reaction notes

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