Ethylene Glycol → 1-[2-(5,5-Dimethyl-1,3-dioxan-2-yl)-4-methoxy-3-(methoxymethoxy)anilino]-3-(2,4-dimethylphenoxy)propan-2-ol
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:20][CH3:21])[c:6]([O:16][CH2:17][O:18][CH3:19])[c:7]1[CH:8]1[O:9][CH2:10][C:11]([CH3:14])([CH3:15])[CH2:12][O:13]1.[CH3:48][CH:49]([OH:50])[CH3:51].[Cu:52][I:53].[K+:45].[K+:46].[K+:47].[NH2:22][CH2:23][CH:24]([CH2:25][O:26][c:27]1[c:28]([CH3:34])[cH:29][c:30]([CH3:33])[cH:31][cH:32]1)[OH:35].[OH:36][CH2:37][CH2:38][OH:39].[P:40]([O-:41])([O-:42])([O-:43])=[O:44]>>[c:2]1([NH:22][CH2:23][CH:24]([CH2:25][O:26][c:27]2[c:28]([CH3:34])[cH:29][c:30]([CH3:33])[cH:31][cH:32]2)[OH:35])[cH:3][cH:4][c:5]([O:20][CH3:21])[c:6]([O:16][CH2:17][O:18][CH3:19])[c:7]1[CH:8]1[O:9][CH2:10][C:11]([CH3:14])([CH3:15])[CH2:12][O:13]1Participants
8
Reactant 7
HCID 174Ethylene Glycol
HCID 813Potassium Cation3×
HCID 1061Phosphate
HCID 3776Isopropanol
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 33871311-Amino-3-(2,4-dimethylphenoxy)propan-2-ol
HCID 597618382-(6-Bromo-3-methoxy-2-methoxymethoxy-phenyl)-5,5-dimethyl-[1,3]dioxaneProduct 1
Sources & evidence
- ORD record
- ord-abb965981d6748a6b3ec89179af90ede
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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