4-Methoxybenzylamine → 3-(4-Methoxybenzylamino)methylenedihydrofuran-2-one

HRID 80335Notes

Reaction equation

[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>>[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:17][CH:3]=[C:4]2[CH2:8][CH2:7][O:6][C:5]2=[O:9])=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 754524-Methoxybenzylamine

HCID 66988753HCID 66988753, compound

Product 1

HCID 669882193-(4-Methoxybenzylamino)methylenedihydrofuran-2-oneYield 28%

Procedure

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (50 mmol) and 4-methoxybenzylamine (55 mmol) and proceeding according to the abovementioned method A1, 3-(4-methoxybenzylamino)methylenedihydrofuran-2-one (2.9 g, efficiency: 28%) is produced in the form of a white powder.

Sources & evidence

ORD record: ord-5525dac6a90d456b913a69fa3d2b58c1
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846125B2

Reaction notes

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