Dimethylformamide → 2-Chloro-4-(chloromethyl)-3-methylpyridine

HRID 803444Notes

Reaction equation

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH2:9][OH:10])[c:7]1[CH3:8].[Cl:21][CH2:22][Cl:23].[O:11]=[CH:12][N:13]([CH3:14])[CH3:15].[P:16]([Cl:17])([Cl:18])([Cl:19])=[O:20]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH2:9][Cl:18])[c:7]1[CH3:8]

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 24813Phosphorus oxychloride

HCID 22504279(2-Chloro-3-methylpyridin-4-yl)methanol

Product 1

HCID 185068432-Chloro-4-(chloromethyl)-3-methylpyridine

Sources & evidence

ORD record: ord-a52390e073144c5a8e968222f1d719f7
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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