Hydrochloric Acid → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

HRID 803531Notes

Reaction equation

HRID 803531 reaction equation
[CH3:38][N:39]1[CH2:40][CH2:41][CH2:42][C:43]1=[O:44].[ClH:21].[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]2([C:13]([F:14])([F:15])[F:16])[O:11][CH2:12]2)([CH3:17])[CH3:18])[cH:7]1.[c:22]1(-[n:28]2[n:29][cH:30][c:31]3[c:32]([NH2:37])[cH:33][cH:34][cH:35][c:36]23)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]([OH:11])([CH2:12][NH:37][c:32]2[c:31]3[cH:30][n:29][n:28](-[c:22]4[cH:23][cH:24][cH:25][cH:26][cH:27]4)[c:36]3[cH:35][cH:34][cH:33]2)[C:13]([F:14])([F:15])[F:16])([CH3:17])[CH3:18])[cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 13387N-methyl-2-pyrrolidoneHCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 249380571-phenyl-1H-indazol-4-amine

Product 1

HCID 576159441,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Sources & evidence

ORD record
ord-d372312cc976498cb8b07734ac136566
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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