Hydrochloric Acid → 4-Morpholinopiperidine

HRID 803648Notes

Reaction equation

HRID 803648 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:12][CH2:13]1.[CH3:21][OH:22].[ClH:20].[OH-:23].[OH-:24].[Pd+2:25]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 7838314-(1-Benzylpiperidin-4-yl)morpholine

Product 1

HCID 7957244-Morpholinopiperidine

Sources & evidence

ORD record
ord-a4660276230e4c6b9636a94c9b9e6ba1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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