Tetrahydrofuran → 3-(4-Fluorobenzyl)-7-(tetrahydro-2H-pyran-2-yloxy)-7,8,9,10-tetrahydropyrrolo[3',2':4,5]pyrido[2,3-c]azepin-6(3H)-one

HRID 803823Notes

Reaction equation

HRID 803823 reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[cH:8][cH:9][c:10]3[c:11]2[cH:12][n:13][c:14]([C:20](=[O:21])[NH:22][O:23][CH:24]2[O:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[c:15]3[CH2:16][CH2:17][CH2:18][OH:19])[cH:30][cH:31]1.[O:51]=[C:52]([O:53][CH:54]([CH3:55])[CH3:56])[N:57]=[N:58][C:59]([O:60][CH:61]([CH3:62])[CH3:63])=[O:64].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[cH:8][cH:9][c:10]3[c:11]2[cH:12][n:13][c:14]2[c:15]3[CH2:16][CH2:17][CH2:18][N:22]([O:23][CH:24]3[O:25][CH2:26][CH2:27][CH2:28][CH2:29]3)[C:20]2=[O:21])[cH:30][cH:31]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 866021111-(4-fluorobenzyl)-4-(3-hydroxypropyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1H-pyrrolo[2,3-c]pyridine-5-carboxamide

Product 1

HCID 686651933-(4-Fluorobenzyl)-7-(tetrahydro-2H-pyran-2-yloxy)-7,8,9,10-tetrahydropyrrolo[3',2':4,5]pyrido[2,3-c]azepin-6(3H)-one

Sources & evidence

ORD record
ord-f71ae40dbff940869798ee8dd3a2ec2a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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