Dimethyl Sulfoxide → 2-((4-Carbamoyl-3-fluorophenyl)amino)-2-methylpropanoic acid

HRID 803946Notes

Reaction equation

HRID 803946 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[NH2:8])[cH:9][cH:10]1.[C:25]([CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][C:31]1=[O:32])(=[O:33])[CH3:34].[CH3:43][S:44]([CH3:45])=[O:46].[Cu:41][I:42].[K+:19].[K+:20].[NH2:12][C:13]([C:14](=[O:15])[OH:16])([CH3:17])[CH3:18].[O-:21][C:22]([O-:23])=[O:24].[O:35]=[CH:36][N:37]([CH3:38])[CH3:39].[OH2:40]>>[c:2]1([NH:12][C:13]([C:14](=[O:15])[OH:16])([CH3:17])[CH3:18])[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[NH2:8])[cH:9][cH:10]1

Participants

10

Reactant 9

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 6119Aminoisobutyric acidHCID 6228DimethylformamideHCID 134002-AcetylcyclohexanoneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27733314-Bromo-2-fluorobenzamide

Product 1

HCID 666179022-((4-Carbamoyl-3-fluorophenyl)amino)-2-methylpropanoic acid

Sources & evidence

ORD record
ord-89f6891eda12474aad413bc240298c5a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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